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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T61386 | CXCR2 antagonist 2 | ||
CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM. | |||
T7681 | AZD-5069 | CXCR | |
AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM). | |||
T7130 | Navarixin | MK-7123,SCH 527123 | CXCR |
Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be benef... | |||
T14384 | AZD8797 | KAN-0440567,KAND567 | CXCR |
AZD8797 (KAND567) is an orally available, selective and potent human CX3CR1-converting antagonist with inhibitory effects on CX3CR1 and CXCR2, and potentially protects against SARS-CoV-2-induced neuronal damage, preventi... | |||
T36443 | (R,R)-CXCR2-IN-2 | (R,R)-CXCR2-IN-2 | |
(R,R)-CXCR2-IN-2, a diastereoisomer of CXCR2-IN-2 (compound 68), functions as a brain-penetrant CXCR2 antagonist. It exhibits a pIC50 of 9 in the Tango assay and 6.8 in the HWB Gro-α induced CD11b expression assay[1]. | |||
T61356 | CXCR2 antagonist 3 | ||
CXCR2 antagonist 3 (compound 11h) is a highly effective antagonist of CXC chemokine receptor 2 (CXCR2). It displays potent activity in inhibiting neutrophil infiltration into the air pouch, with double-digit nanomolar po... | |||
T36923 | CXCR2-IN-2 | CXCR2-IN-2 | |
CXCR2-IN-2 is a selective CXCR2 antagonist that is brain penetrant and orally bioavailable, with IC50 values of 5.2 nM and 1 nM in the β-arrestin assay and CXCR2 Tango assay, respectively. It exhibits approximately 730-f... | |||
T38850 | AZD4721 | RIST4721,AZD4721 | |
AZD4721 (RIST4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 ( CXCR2 ). AZD4721 has the potential for the research of inflammatory disease. |